While his point was that you should live your life, not be consumed by preconceived inhibitions, the phrase certainly still rings true in modern day Hollywood.
Be it from substance abuse or other tragic circumstances, some of the world's most beloved stars have met an untimely end long before they should have.
From Philip Seymour Hoffman's heroin overdose and Paul Walker's fatal car crash to some whose deaths remained shrouded in mystery, it's a long list.
Scroll through The Hollywood Gossip's gallery of 21 shocking celebrity deaths below as we look back on some of the brightest stars who we lost too soon.
Philip Seymour Hoffman passed away at the age of 46. He was found with a needle in his arm and had a history of drug abuse.
1. Philip Seymour Hoffman Philip Seymour Hoffman passed away at the age of 46. He was found with a needle in his arm and had a history of drug abuse.
2. Cory Monteith Cory Monteith was 27 years old when he passed away. He overdosed on drugs during a night of partying in Vancouver.
3. Heath Ledger Heath Ledger left us with one final, amazing performance. He earned an Oscar for his work as The Joker.
4. Paul Walker Paul Walker died in a car accident on November 30, 2013. He left behind a daughter and a burgeoning film career.
5. Gia Allemand Gia Allemand was only 29 when she died. The former Bachelor contestant took her own life.
6. James Gandolfini James Gandolfini will always be remembered as Tony Soprano. He died of a heart attack at the age of 51.
7. Amy Winehouse Amy Winehouse lived a hard life. She died of a drug overdose on July 23, 2011.
8. Gary Coleman Rest in peace, Gary Coleman. The sitcom star left this world at the age from an intercranial hemorrhage.
9. Corey Haim We lost Corey Haim to a reported drug overdose in March 2010. He is remembered for a number of roles, such as Lost Boys.
10. Brittany Murphy Brittany Murphy poses here at the 2009 Video Music Awards. She passed away at the age of 32.
11. Michael Jackson Celebrity death don't hit the world harder than that of Michael Jackson. He was 50 years old when he passed away.
12. Tupac Shakur Tupac Shakur poses here with his mother. The rapper was gunned down at the age of 25.
13. Aaliyah The music world lost Aaliyah in 2001. She died in a plane crash.
14. Tim Russert Tim Russert was as respected as it gets in the world of journalism. He died in 2008.
15. Lisa "Left Eye" Lopes Lisa "Left Eye" Lopes was a key part of TLC. She was killed in a car accident.
16. Whitney Houston Whitney Houston passed away the night before the Grammys. She overdosed in a hotel bathtub.
17. Princess Diana Princess Diana was taken from us in 1997. The iconic figure died in a car crash.
18. Kurt Cobain Rest in peace, Kurt Cobain. The rocker committed suicide in 1997.
19. Anna Nicole Smith Anna Nicole Smith died at the young age of 39. She lived a very troubled life.
20. Biggie Smalls Biggie Smalls got caught up in the East Coast/West Coast rap war. He was killed in 1997.
21. Natasha Richardson Natasha Richardson was married to Liam Neeson at the time of her death. She passed away from a skiing accident.
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