Giuliana Rancic's infertility struggles have been long documented in the media.
In another devastating blow, Rancic's last remaining viable embryo was lost when her surrogate had a miscarriage.
In an interview with People Magazine, Rancic reveals that she and her husband, Bill, found out about the latest miscarriage on New Years Eve:
"It was painful. Were were so optimistic with this last embryo," Rancic explains.
"We thought, 'This is definitely going to work. This is our last shot."
Giuliana and Bill welcomed their son, Duke, in 2012 via surrogacy. After being diagnosed with breast cancer in 2011, Rancic decided to freeze four of her embryos.
After their son was born, they had two of the three remaining embryos implanted, but they were lost as well in a miscarriage only a few weeks later.
Getting pregnant herself would be inherently risky for the 40-year-old E! News host, she says, due to her cancer-suppressing medication.
However, Giuliana and Bill are open to alternatives, including adoption:
"We're open to everything. I think adoption is a beautiful gift you're giving each other."
"And it's funny, I'm even more open to [adoption] than I was before. Because I think to myself, 'I love Duke so much, if I couldn't take care of him, I hope there would be someone else who would love him.'"
The rampant media and online criticism of Giuliana Rancic's weight also warrants a mention, and she attributes that to her medication, saying, "It's really hurtful."
"I'm sorry that some people think I'm 'disgustingly skinny,' as they put it, but there's nothing I can do. I'm lucky that I even have the type of cancer that reacts to the medicine."
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Alec Baldwin and wife Hilaria are expecting their second child together, as seen here. Alec also has an older daughter, Ireland, from his marriage to Kim Basinger.
Chad Michael Murray and Sarah Roemer are married, having tied the knot in secret! They're also expecting their first child! Talk about a two-for-one surprise!
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